The abstract below suggests that the typical treatment for epididymitis in younger men may not be effective when Chlamydia is present.

Persistence of Chlamydia trachomatis Is Induced by Ciprofloxacin and Ofloxacin In Vitro

Antimicrobial Agents and Chemotherapy
December 2000, p. 3288-3297, Vol. 44, No. 12

Ute Dreses-Werringloer1, Ingrid Padubrin1, Barbara Jurgens-Saathoff1, Alan P. Hudson2, H. Zeidler1, and L. Kohler1,
Department of Rheumatology, Hannover Medical School, Hannover, Germany1, and Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 492012

Incubation of established chlamydial cultures with ciprofloxacin and ofloxacin not only failed to eradicate the organism from host cells, but rather induced a state of chlamydial persistence. This state was characterized by the presence of nonculturable, but fully viable, bacteria and the development of aberrant inclusions.